Patterns of Co-occurring Comorbidities in People Living With HIV.

ABSTRACT:

Background

The aims of this study were to identify common patterns of comorbidities observed in people living with HIV (PLWH), using a data-driven approach, and evaluate associations between patterns identified.

Methods

A wide range of comorbidities were assessed in PLWH participating in 2 independent cohorts (POPPY: UK/Ireland; AGE_hIV: Netherlands). The presence/absence of each comorbidity was determined using a mix of self-reported medical history, concomitant medications, health care resource use, and laboratory parameters. Principal component analysis (PCA) based on Somers' D statistic was applied to identify patterns of comorbidities.

Results

PCA identified 6 patterns among the 1073 POPPY PLWH (85.2% male; median age [interquartile range {IQR}],

SUBMITTER: De Francesco D 

PROVIDER: S-EPMC6239080 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature