High expression of TFEB is associated with aggressive clinical features in colorectal cancer.

ABSTRACT:

Objectives

The transcription factor EB (TFEB), a member of the micropthalmia family, has been found to be associated with autophagy and upregulated in some kinds of tumors. However, very few studies focused on TFEB in colorectal cancer (CRC). TFEB expression status and its relevance to clinical features in CRC would be analyzed in this study.

Materials and methods

Real-time PCR, Western blot, and immunohistological staining were used to evaluate TFEB expression in CRC tissues and adjacent normal tissues, and the role of TFEB in CRC cell lines was investigated in vitro and in vivo.

Results

TFEB was expressed at lower level in CRC tissues than normal in both mRNA and protein level. However, there were significantly positive correlations between TFEB expression in cancer

SUBMITTER: Liang J 

PROVIDER: S-EPMC6239122 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature