Understanding sex differences in the regulation of cancer-induced muscle wasting.

ABSTRACT:

Purpose of review

We highlight evidence for sexual dimorphism in preclinical and clinical studies investigating the cause and treatment of cancer cachexia.

Recent findings

Cancer cachexia is unintended bodyweight loss occurring with cancer, and skeletal muscle wasting is a critical predictor of negative outcomes in the cancer patient. Skeletal muscle exhibits sexual dimorphism in fiber type, function, and regeneration capacity. Sex differences have been implicated in skeletal muscle metabolism, mitochondrial function, immune response to injury, and myogenic stem cell regulation. All of these processes have the potential to be involved in cancer-induced muscle wasting. Unfortunately, the vast majority of published studies examining cancer cachexia in preclinical models or can

SUBMITTER: Montalvo RN 

PROVIDER: S-EPMC6239206 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature