The association of POLR2E rs3787016 polymorphism and cancer risk: a Chinese case-control study and meta-analysis.

ABSTRACT: How single nucleotide polymorphisms in long non-coding RNAs are involved in cancer susceptibility remains poorly understood. We hypothesized that polymerase II polypeptide E (POLR2E) rs3787016 polymorphism, identified in a genome-wide association study of prostate cancer, might be a common genetic risk factor for cancer risk. To address this issue, we here conducted a case-control study to investigate the association of POLR2E rs3787016 polymorphism with risk of liver and lung cancer (including 800 normal controls, 480 liver cancer patients, and 550 lung cancer patients), followed by a meta-analysis. The genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism and confirmed by sequencing. Although no significant association was found for

SUBMITTER: Chen B 

PROVIDER: S-EPMC6239260 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature