ANTAGONISTIC HETEROGENEITY IN GENETICS OF LIPID TRAITS: IMPLICATIONS TO THE CETP LOCUS

ABSTRACT: Abstract Preventive medicine is a promising approach in geroscience to avoid diseases by targeting underlying risk factors. Recently, Cholesteryl Ester Transfer Protein (CETP) was considered a target for decreasing risks of cardio-vascular diseases by increasing high-density lipoprotein cholesterol (HDL-C), although clinical trials failed demonstrating limited understanding of the underlying mechanisms in this locus. We examined in detail the associations of the CETP genetic markers with lipids in seven large-scale cohorts (ARIC, CHS, CARDIA, FHS, HRS, MESA, WHI) comprised of 29,902 Caucasians. Our analyses identified rs1532625 polymorphism demonstrating the strongest association with HDL-C at genome-wide level in this locus; moderate association with total cholesterol (TC) partially media

SUBMITTER: Loika Y 

PROVIDER: S-EPMC6239387 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature