Ontology highlight
ABSTRACT:
SUBMITTER: Biton M
PROVIDER: S-EPMC6239889 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Cell 20181101 5
In the small intestine, a niche of accessory cell types supports the generation of mature epithelial cell types from intestinal stem cells (ISCs). It is unclear, however, if and how immune cells in the niche affect ISC fate or the balance between self-renewal and differentiation. Here, we use single-cell RNA sequencing (scRNA-seq) to identify MHC class II (MHCII) machinery enrichment in two subsets of Lgr5<sup>+</sup> ISCs. We show that MHCII<sup>+</sup> Lgr5<sup>+</sup> ISCs are non-conventiona ...[more]