Molecular dissection of cone photoreceptor-enriched genes encoding transmembrane and secretory proteins.

ABSTRACT: Cone photoreceptors mediate color perception and daylight vision through intricate synaptic circuitry. In most mammalian retina, cones are greatly outnumbered by rods and exhibit inter-dependence for functional maintenance and survival. Currently, we have limited understanding of cone-specific molecular components that mediate response to extrinsic signaling factors or are involved in communication with rods and other retinal cells. To fulfill this gap, we compared the recently-published transcriptomes of developing S-cone-like photoreceptors from the Nrl^-/- mouse retina with those of rods and identified candidate genes responsible for cone cell functions and communication. We generated an in silico expression profile of 823 genes that encode candidate transmembrane and secretor

SUBMITTER: Papal S 

PROVIDER: S-EPMC6239890 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature