Astrocyte Elevated Gene-1 Regulates Macrophage Activation in Hepatocellular Carcinogenesis.

ABSTRACT: Chronic inflammation is a known hallmark of cancer and is central to the onset and progression of hepatocellular carcinoma (HCC). Hepatic macrophages play a critical role in the inflammatory process leading to HCC. The oncogene Astrocyte elevated gene-1 (AEG-1) regulates NFκB activation, and germline knockout of AEG-1 in mice (AEG-1^-/-) results in resistance to inflammation and experimental HCC. In this study, we developed conditional hepatocyte- and myeloid cell-specific AEG-1^-/- mice (AEG-1^ΔHEP and AEG-1^ΔMAC, respectively) and induced HCC by treatment with N-nitrosodiethylamine (DEN) and phenobarbital (PB). AEG-1^ΔHEP mice exhibited a significant reduction in disease severity compared with control littermates, while AEG-

SUBMITTER: Robertson CL 

PROVIDER: S-EPMC6239947 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature