Cryo-EM for Small Molecules Discovery, Design, Understanding, and Application.

ABSTRACT: We present a perspective of our view of the application of cryoelectron microscopy (cryo-EM) to structure-based drug design (SBDD). We discuss the basic needs and requirements for SBDD, the current state of cryo-EM, and the challenges that need to be overcome for this technique to reach its full potential in facilitating the process of drug discovery.

SUBMITTER: Scapin G 

PROVIDER: S-EPMC6239957 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature