Amnion epithelial cell-derived exosomes induce inflammatory changes in uterine cells.

ABSTRACT: BACKGROUND:Fetal endocrine signals are generally considered to contribute to the timing of birth and the initiation of labor. Fetal tissues under oxidative stress release inflammatory mediators that lead to sterile inflammation within the maternal-fetal interface. Importantly, these inflammatory mediators are packaged into exosomes, bioactive cell-derived extra cellular vesicles that function as vectors and transport them from the fetal side to the uterine tissues where they deposit their cargo into target cells enhancing uterine inflammatory load. This exosome-mediated signaling is a novel mechanism for fetal-maternal communication. OBJECTIVE:This report tested the hypothesis that oxidative stress can induce fetal amnion cells to produce exosomes, which function as a paracrine intermediar

SUBMITTER: Hadley EE 

PROVIDER: S-EPMC6239974 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature