Ontology highlight
ABSTRACT:
SUBMITTER: Choi W
PROVIDER: S-EPMC6240035 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Nature communications 20181116 1
Nonalcoholic fatty liver disease (NAFLD) is increasing in worldwide prevalence, closely tracking the obesity epidemic, but specific pharmaceutical treatments for NAFLD are lacking. Defining the key molecular pathways underlying the pathogenesis of NAFLD is essential for developing new drugs. Here we demonstrate that inhibition of gut-derived serotonin synthesis ameliorates hepatic steatosis through a reduction in liver serotonin receptor 2A (HTR2A) signaling. Local serotonin concentrations in th ...[more]