Developmental changes of cortical white-gray contrast as predictors of autism diagnosis and severity.

ABSTRACT: Recent studies suggest that both cortical gray and white-matter microstructural characteristics are distinct for subjects with autism. There is a lack of evidence regarding how these characteristics change in a developmental context. We analysed a longitudinal/cross-sectional dataset of 402 magnetic resonance imaging (MRI) scans (171 subjects with autism and 231 with typical development) from the Autism Brain Imaging Data Exchange, cohorts I-II (ABIDE-I-II). In the longitudinal sample, we computed the rate of change in the white-gray contrast, a measure which has been related to age and cognitive performance, at the boundary of the cerebral cortex. Then, we devised an analogous metric for the cross-sectional sample of the ABIDE dataset to measure age-related differences in cortical contras

SUBMITTER: Bezgin G 

PROVIDER: S-EPMC6240045 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature