Asymmetry in Mechanosensitive Gene Expression during Aortic Arch Morphogenesis.

ABSTRACT: Embryonic aortic arches (AA) are initially bilaterally paired, transitional vessels and failures in remodeling based on hemodynamic and growth-related adaptations cause a spectrum of congenital heart disease (CHD) anatomies. Identifying regulatory mechanisms and cross-talk between the genetic elements of these vessels are critical to understand the ethiology of CHD and refine predictive computational models. This study aims to screen expression profiles of fundamental biological pathways in AA at early stages of chick embryo morphogenesis and correlate them with our current understanding of growth and mechanical loading. Reverse transcription-quantitative PCR (RT-qPCR) was followed by correlation and novel peak expression analyses to compare the behaviour and activation period of the genes

SUBMITTER: Karakaya C 

PROVIDER: S-EPMC6240117 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature