Reversal of albuminuria by combined AM6545 and perindopril therapy in experimental diabetic nephropathy.

ABSTRACT:

Background and purpose

The endocannabinoid (EC) system has been implicated in the pathogenesis of diabetic nephropathy (DN). We investigated the effects of peripheral blockade of the cannabinoid CB₁ receptor as an add-on treatment to ACE-inhibition in type 1 diabetic mice (DM) with established albuminuria.

Experimental approach

Renal functional parameters (albumin excretion rate, creatinine clearance), tubular injury, renal structure, both EC and CB receptor levels and markers of podocyte dysfunction, fibrosis and inflammation were studied in streptozotocin-induced DM treated for 14 weeks with vehicle, the ACE-inhibitor perindopril (2 mg·kg^-1 ·day^-1 ), peripherally-restricted CB₁ receptor antagonist AM6545 (10 mg·kg^-1 ·d

SUBMITTER: Barutta F 

PROVIDER: S-EPMC6240130 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature