A prediction model for primary aldosteronism when the salt loading test is inconclusive.

ABSTRACT:

Objective

To develop a prediction model to confirm or exclude primary aldosteronism (PA) in patients with an inconclusive salt loading test (SLT).

Context

Diagnosis in patients with a suspicion of PA can be confirmed using an SLT. In case of inconclusive test results the decision about how to manage the patient is usually based on contextual clinical data.

Design

We included a retrospective cohort of 276 patients in the final analysis.

Methods

All patients underwent an SLT between 2005 and 2016 in our university medical center. The SLT was inconclusive (post-infusion aldosterone levels 140-280 pmol/L) in 115 patients. An expert panel then used contextual clinical data to diagnose PA in 45 of them. Together with 101 patients with a positive SLT this resulted in

SUBMITTER: Velema MS 

PROVIDER: S-EPMC6240140 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature