Severe ophthalmic manifestation in pituitary-involved granulomatosis with polyangiitis: a case report and literature review.

ABSTRACT:

Background

Granulomatosis with polyangiitis (GPA), a necrotizing granulomatous disease, very rarely involves the central nervous system (CNS), particularly the pituitary. Delayed treatment may cause permanent bilateral blindness. We report an isolated case of pituitary GPA that manifested as a progressive bilateral temporal visual field (VF) defect and was diagnosed via pituitary biopsy. Additionally, we review ocular, chiasmal and cranial nerve involvement in pituitary GPA.

Case presentation

A 20-year-old Chinese man was referred for repeated fever, sudden headache, diplopia with a bilateral best-corrected visual acuity (BCVA) of 10/20, ptosis in both eyes and restricted abduction on the right side. VF tests showed bitemporal hemianopsia. Laboratory tests revealed hypothyro

SUBMITTER: Zhang X 

PROVIDER: S-EPMC6240177 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature