Whole-genome sequencing and analysis of Plasmodium falciparum isolates from China-Myanmar border area.

ABSTRACT:

Background

China has made progress in malaria control and aims to eliminate malaria nationwide, but implementing effective interventions along the border regions remain a huge task. The Plasmodium falciparum cases imported from Southeast Asia has frequently reported especially in the China-Myanmar border (CMB) area. Though, information is scant on P. falciparum genetic variability in this area.

Methods

This study reported P. falciparum isolates genome sequence of six clinical isolates in the CMB area. Furthermore, we estimated the nucleotide diversity, Watterson's estimator and Tajima's D value for the whole genome mutation rate in slide window.

Results

Our data were aligned onto 96.05-98.61% of the reference 3D7 genome in high fold coverages. Principal component anal

SUBMITTER: Shen HM 

PROVIDER: S-EPMC6240207 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature