Association of serum angiopoietin-2 with malnutrition, inflammation, atherosclerosis and valvular calcification syndrome and outcome in peritoneal dialysis patients: a prospective cohort study.

ABSTRACT:

Background

To examine serum angiopoietin-2 (Angpt-2) in relation to malnutrition, inflammation, atherosclerosis and cardiac valvular calcification, so-called MIAC syndrome and its predictive role in outcomes of peritoneal dialysis (PD) patients.

Methods

A prospective observational study was conducted in 324 chronic PD patients. Biochemical analysis was performed at baseline for serum angiopoietins, albumin and high sensitive C-reactive protein (hs-CRP) and echocardiography was done to detect cardiac valvular calcification. Primary study end points were fatal or nonfatal cardiovascular events and mortality.

Results

The median of serum Angpt-2 levels was 5.44 ng/mL (interquartile range, 3.41-7.85). Across the three tertiles of serum Angpt-2, a significant trend effect w

SUBMITTER: Yang X 

PROVIDER: S-EPMC6240212 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature