Neurogenesis in the sea urchin embryo is initiated uniquely in three domains.

ABSTRACT: Many marine larvae begin feeding within a day of fertilization, thus requiring rapid development of a nervous system to coordinate feeding activities. Here, we examine the patterning and specification of early neurogenesis in sea urchin embryos. Lineage analysis indicates that neurons arise locally in three regions of the embryo. Perturbation analyses showed that when patterning is disrupted, neurogenesis in the three regions is differentially affected, indicating distinct patterning requirements for each neural domain. Six transcription factors that function during proneural specification were identified and studied in detail. Perturbations of these proneural transcription factors showed that specification occurs differently in each neural domain prior to the Delta-Notch restriction signa

SUBMITTER: McClay DR 

PROVIDER: S-EPMC6240313 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature