Neuromesodermal progenitors are a conserved source of spinal cord with divergent growth dynamics.

ABSTRACT: During gastrulation, embryonic cells become specified into distinct germ layers. In mouse, this continues throughout somitogenesis from a population of bipotent stem cells called neuromesodermal progenitors (NMps). However, the degree of self-renewal associated with NMps in the fast-developing zebrafish embryo is unclear. Using a genetic clone-tracing method, we labelled early embryonic progenitors and found a strong clonal similarity between spinal cord and mesoderm tissues. We followed individual cell lineages using light-sheet imaging, revealing a common neuromesodermal lineage contribution to a subset of spinal cord tissue across the anterior-posterior body axis. An initial population subdivides at mid-gastrula stages and is directly allocated to neural and mesodermal compartments duri

SUBMITTER: Attardi A 

PROVIDER: S-EPMC6240315 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature