Diverse progenitor cells preserve salivary gland ductal architecture after radiation-induced damage.

ABSTRACT: The ductal system of the salivary gland has long been postulated to be resistant to radiation-induced damage, a common side effect incurred by head and neck cancer patients receiving radiotherapy. Yet, whether the ducts are capable of regenerating after genotoxic injury, or whether damage to ductal cells induces lineage plasticity, as has been reported in other organ systems, remains unknown. Here, using the murine salivary gland, we show that two ductal progenitor populations, marked exclusively by KRT14 and KIT, maintain non-overlapping ductal compartments after radiation exposure but do so through distinct cellular mechanisms. KRT14⁺ progenitor cells are fast-cycling cells that proliferate in response to radiation-induced damage in a sustained manner and divide asymmetrically

SUBMITTER: May AJ 

PROVIDER: S-EPMC6240316 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature