Single cell transcriptome analysis of human, marmoset and mouse embryos reveals common and divergent features of preimplantation development.

ABSTRACT: The mouse embryo is the canonical model for mammalian preimplantation development. Recent advances in single cell profiling allow detailed analysis of embryogenesis in other eutherian species, including human, to distinguish conserved from divergent regulatory programs and signalling pathways in the rodent paradigm. Here, we identify and compare transcriptional features of human, marmoset and mouse embryos by single cell RNA-seq. Zygotic genome activation correlates with the presence of polycomb repressive complexes in all three species, while ribosome biogenesis emerges as a predominant attribute in primate embryos, supporting prolonged translation of maternally deposited RNAs. We find that transposable element expression signatures are species, stage and lineage specific. The pluripotenc

SUBMITTER: Boroviak T 

PROVIDER: S-EPMC6240320 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature