How much allopurinol does it take to get to target urate? Comparison of actual dose with creatinine clearance-based dose.

ABSTRACT:

Objective

Allopurinol dosing has frequently been limited based on creatinine clearance (CrCL), resulting in failure to achieve target serum urate (SU). The aim of this analysis was to determine how many milligrams of allopurinol above the recommended CrCL-based dose (R+) are required to achieve target SU and to investigate the factors that influence R+.

Methods

We analysed data from participants in a 24-month open, randomized, controlled, parallel-group, comparative clinical trial. Data obtained during the 12-month dose escalation (DE) phase of the study (year 1 for DE/DE and year 2 for control/DE) were combined. R+ dose was defined as the number of milligrams of allopurinol above the CrCL-based dose at the final visit.

Results

Of the 132 participants, R+ allopurinol

SUBMITTER: Stamp LK 

PROVIDER: S-EPMC6240322 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature