Derivation and validation of plasma endostatin for predicting renal recovery from acute kidney injury: a prospective validation study.

ABSTRACT:

Background

Acute kidney injury (AKI) is associated with high morbidity and mortality in surgical patients. Nonrecovery from AKI may increase mortality and early risk stratification seems key to improving clinical outcomes. The aim of the current study was to explore and validate the value of endostatin for predicting failure to recover from AKI.

Methods

We conducted a prospective cohort study of 198 patients without known chronic kidney disease who underwent noncardiac major surgery and developed new-onset AKI in the first 48 h after admission to the ICU. The biomarkers of plasma endostatin, neutrophil gelatinase-associated lipocalin (NGAL) and cystatin C were detected immediately after AKI diagnosis. The primary endpoint was nonrecovery from AKI (within 7 days). Cutoff valu

SUBMITTER: Jia HM 

PROVIDER: S-EPMC6240328 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature