Development, activation, and therapeutic potential of thermogenic adipocytes.

ABSTRACT: During the last decade, significant progress has been made in understanding adipocytes with a particular focus on thermogenic fat cells, which effectively convert chemical energy into heat in addition to their other metabolic functions. It has been increasingly recognized that different types and subtypes of adipocytes exist and the developmental origins of various types of fat cells are being intensively investigated. Previous work using immortalized fat cell lines has established an intricate transcriptional network that regulates adipocyte function. Recent work has illustrated how these key transcriptional components mediate thermogenic activation in fat cells. Last but not least, cumulative evidence supports an incontestable role of thermogenic fat in influencing systemic metabolism in

SUBMITTER: Emont MP 

PROVIDER: S-EPMC6240366 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature