Ontology highlight
ABSTRACT:
SUBMITTER: Seo M
PROVIDER: S-EPMC6240374 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Journal of molecular medicine (Berlin, Germany) 20181023 12
Chronic obstructive pulmonary disease (COPD) is a leading cause of death worldwide, and long-term oxygen therapy has been shown to reduce mortality in COPD patients with severe hypoxemia. However, the Long-term Oxygen Treatment Trial (LOTT), a large randomized trial, found no benefit of oxygen therapy in COPD patients with moderate hypoxemia. We hypothesized that there may be differences in response to oxygen which depend on genotype or gene expression. In a genome-wide time-to-event analysis of ...[more]