Ripple oscillations in the left temporal neocortex are associated with impaired verbal episodic memory encoding.

ABSTRACT:

Background

We sought to determine if ripple oscillations (80-120 Hz), detected in intracranial electroencephalogram (iEEG) recordings of patients with epilepsy, correlate with an enhancement or disruption of verbal episodic memory encoding.

Methods

We defined ripple and spike events in depth iEEG recordings during list learning in 107 patients with focal epilepsy. We used logistic regression models (LRMs) to investigate the relationship between the occurrence of ripple and spike events during word presentation and the odds of successful word recall following a distractor epoch and included the seizure onset zone (SOZ) as a covariate in the LRMs.

Results

We detected events during 58,312 word presentation trials from 7630 unique electrode sites. The probability of rippl

SUBMITTER: Waldman ZJ 

PROVIDER: S-EPMC6240385 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature