When pain gets stuck: the evolution of pain chronification and treatment resistance.

ABSTRACT: It is well-recognized that, despite similar pain characteristics, some people with chronic pain recover, whereas others do not. In this review, we discuss possible contributions and interactions of biological, social, and psychological perturbations that underlie the evolution of treatment-resistant chronic pain. Behavior and brain are intimately implicated in the production and maintenance of perception. Our understandings of potential mechanisms that produce or exacerbate persistent pain remain relatively unclear. We provide an overview of these interactions and how differences in relative contribution of dimensions such as stress, age, genetics, environment, and immune responsivity may produce different risk profiles for disease development, pain severity, and chronicity. We propose the

SUBMITTER: Borsook D 

PROVIDER: S-EPMC6240430 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature