Genetic evaluation of patients with non-syndromic male infertility.

ABSTRACT:

Purpose

This review provides an update on the genetics of male infertility with emphasis on the current state of research, the genetic disorders that can lead to non-syndromic male infertility, and the genetic tests available for patients.

Methods

A comprehensive review of the scientific literature referenced in PubMed was conducted using keywords related to male infertility and genetics. The search included articles with English abstracts appearing online after 2000.

Results

Mutations in 31 distinct genes have been identified as a cause of non-syndromic human male infertility, and the number is increasing constantly. Screening gene panels by high-throughput sequencing can be offered to patients in order to identify genes involved in various forms of human non-syndrom

SUBMITTER: Okutman O 

PROVIDER: S-EPMC6240550 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature