NMR metabolomics study of follicular fluid in women with cancer resorting to fertility preservation.

ABSTRACT:

Purpose

The purpose of this study was to evaluate the possible application of metabolomics to identify follicular fluid changes in cancer patients undergoing fertility preservation. Although metabolomics have been applied already in cancer studies, this is the first application on follicular fluid of cancer patients.

Methods

We selected for the study ten patients with breast cancer and lymphoma who resorted to oocyte cryopreservation to preserve fertility and ten healthy women undergoing in vitro fertilization treatments. Follicular fluid was collected at the time of oocytes retrieval. Metabolomic analysis of follicular fluids was performed by ¹H-nuclear magnetic resonance (NMR) spectroscopy in combination with multivariate analysis to interpret the spectral data.

SUBMITTER: Castiglione Morelli MA 

PROVIDER: S-EPMC6240554 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature