Serum Periostin Levels: A Potential Serologic Marker for Toluene Diisocyanate-Induced Occupational Asthma.

ABSTRACT:

Purpose

Toluene diisocyanate (TDI) is a leading cause of occupational asthma (OA). Periostin is a matricellular protein implicated in type 2 immunity-driven asthma. Its pathogenic role in TDI-OA has not been completely elucidated. The present study was performed to investigate the role of periostin in TDI-OA.

Materials and methods

Serum periostin levels were measured in subjects with TDI-OA, asymptomatic TDI-exposure controls (AECs), non-occupational asthmatics (NAs), and unexposed normal controls (NCs). To understand the mechanism by which TDI induces periostin production, primary small airway epithelial cells (SAECs) were cultured under stimulation of TDI and neutrophils from asthmatic patients.

Results

Fifty-three subjects with TDI-OA, 71 AECs, 67 NAs, and 83 NCs w

SUBMITTER: Lee JH 

PROVIDER: S-EPMC6240562 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature