Hypertension Risk with Abacavir Use among HIV-Infected Individuals: A Nationwide Cohort Study.

ABSTRACT:

Purpose

A high risk of cardiovascular disease (CVD) is reported for HIV-infected individuals. While a link between abacavir and CVD risk is suggested, an association between abacavir and hypertension remains unclear. This study evaluated hypertension risk with abacavir use in comparison to non-abacavir antiretroviral treatment (ART).

Materials and methods

From a nationwide cohort of HIV-infected individuals on their initial ART, 6493 who were free of hypertension at baseline were analyzed. The use of ART was treated as a time-varying covariate measured as a daily unit. Incidence rate of hypertension was calculated, and Cox proportional hazard models were used to estimate adjusted hazard ratios (HRs) with 95% confidence interval (CI) of incident hypertension overall and among

SUBMITTER: Kim J 

PROVIDER: S-EPMC6240567 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature