Improvement of Duchenne muscular dystrophy phenotype following obestatin treatment.

ABSTRACT:

Background

This study was performed to test the therapeutic potential of obestatin, an autocrine anabolic factor regulating skeletal muscle repair, to ameliorate the Duchenne muscular dystrophy (DMD) phenotype.

Methods and results

Using a multidisciplinary approach, we characterized the ageing-related preproghrelin/GPR39 expression patterns in tibialis anterior (TA) muscles of 4-, 8-, and 18-week-old mdx mice (n = 3/group) and established the effects of obestatin administration at this level in 8-week-old mdx mice (n = 5/group). The findings were extended to in vitro effects on human immortalized DMD myotubes. An analysis of TAs revealed an age-related loss of preproghrelin expression, as precursor of obestatin, in mdx mice. Administration of obestatin resulted in a signific

SUBMITTER: Gonzalez-Sanchez J 

PROVIDER: S-EPMC6240759 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature