Dataset Information

Preoperative BRAF inhibition in patients with irresectable locally advanced stage III melanoma.

ABSTRACT:

Aim

Neoadjuvant treatment of locally advanced disease with BRAF inhibitors is expected to increase the likelihood of a R0 resection. We present six patients with stage III unresectable melanoma, neoadjuvantly treated with BRAF inhibitors.

Methods

Patients with unresectable, BRAF-mutated, stage III melanoma, were treated with BRAF inhibitors between 2012 and 2015. Unresectability was determined based on clinical and/or radiological findings. At maximal response, resection was performed. The specimen was reviewed to determine the degree of response.

Results

In five of six patients a radical resection was achieved. Postoperative complications were unremarkable. In five of six resected specimens, vital tumor tissue was found.

Conclusion

Neoadjuvant BRAF inhibitor treatment of locally advanced melanoma is feasible and has the potential to facilitate an R0 resection.

SUBMITTER: Faut M

PROVIDER: S-EPMC6240848 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature

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Publications

Preoperative <i>BRAF</i> inhibition in patients with irresectable locally advanced stage III melanoma.

Faut Marloes M Jalving Mathilde M Diercks Gilles F GF Hospers Geke A GA van Leeuwen Barbara L BL Been Lukas B LB

Melanoma management 20180516 2

<h4>Aim</h4>Neoadjuvant treatment of locally advanced disease with <i>BRAF</i> inhibitors is expected to increase the likelihood of a R0 resection. We present six patients with stage III unresectable melanoma, neoadjuvantly treated with <i>BRAF</i> inhibitors.<h4>Methods</h4>Patients with unresectable, <i>BRAF</i>-mutated, stage III melanoma, were treated with <i>BRAF</i> inhibitors between 2012 and 2015. Unresectability was determined based on clinical and/or radiological findings. At maximal r ...[more]

PMID: 30459939

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