Preoperative BRAF inhibition in patients with irresectable locally advanced stage III melanoma.

ABSTRACT:

Aim

Neoadjuvant treatment of locally advanced disease with BRAF inhibitors is expected to increase the likelihood of a R0 resection. We present six patients with stage III unresectable melanoma, neoadjuvantly treated with BRAF inhibitors.

Methods

Patients with unresectable, BRAF-mutated, stage III melanoma, were treated with BRAF inhibitors between 2012 and 2015. Unresectability was determined based on clinical and/or radiological findings. At maximal response, resection was performed. The specimen was reviewed to determine the degree of response.

Results

In five of six patients a radical resection was achieved. Postoperative complications were unremarkable. In five of six resected specimens, vital tumor tissue was found.

Conclusion

SUBMITTER: Faut M 

PROVIDER: S-EPMC6240848 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature