Redox-triggered cascade dearomative cyclizations enabled by hexafluoroisopropanol.

ABSTRACT: An unprecedented cascade dearomative cyclization through hydrogen-bonding-assisted hydride transfer is realized. The aggregate effect of HFIP enables the rapid buildup of polycyclic amines directly from phenols and o-aminobenzaldehydes via a cascade dearomatization/rearomatization/dearomatization sequence. This unique transformation addressed the drawbacks of hydride transfer-involved redox-neutral reactions.

SUBMITTER: Li SS 

PROVIDER: S-EPMC6240893 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature