Fetal cord blood and tissue immune responses to chronic placental inflammation and chorioamnionitis.

ABSTRACT:

Background

Chorioamnionitis is a risk factor for future asthma development. Animal models of chorioamnionitis demonstrate increased T_H17-to-T_reg ratios associated with proinflammatory cytokine elevations. The association of chorioamnionitis on human neonatal immune cells systemically and within tissues is not known.

Methods

We enrolled two cohorts to evaluate T_H17 and regulatory T cell (T_reg) phenotypic markers in chorioamnionitis. From a cohort of 19 live birth infants, we collected cord blood and placenta samples to evaluate for signs of acute and chronic histologic inflammation and cell phenotype characterization. We analyzed a second cohort of stillborn infants with and without chorioamnionitis to classify and enumerate cell in

SUBMITTER: Singh AM 

PROVIDER: S-EPMC6240933 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature