Patient-derived Models Reveal Impact of the Tumor Microenvironment on Therapeutic Response.

ABSTRACT:

Background

Androgen deprivation therapy is a first-line treatment for disseminated prostate cancer (PCa). However, virtually all tumors become resistant and recur as castration-resistant PCa, which has no durable cure. One major hurdle in the development of more effective therapies is the lack of preclinical models that adequately recapitulate the heterogeneity of PCa, significantly hindering the ability to accurately predict therapeutic response.

Objective

To leverage the ex vivo culture method termed patient-derived explant (PDE) to examine the impact of PCa therapeutics on a patient-by-patient basis.

Design setting and participants

Fresh PCa tissue from patients who underwent radical prostatectomy was cultured as PDEs to examine therapeutic response.

Outc

SUBMITTER: Shafi AA 

PROVIDER: S-EPMC6241309 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature