RNA Sequencing Reveals the Suitability of Cardiac Death Livers for Transplantation.

ABSTRACT:

Background

Organ transplantation is considered the best treatment for end-stage organ failure. However, the lack of available organs for transplantation and the increasing number of patients waiting for transplants are primary issues facing the transplant community. Thus, developing strategies to increase the number of donors, especially for liver transplantation, has become a priority. The use of organs acquired from donors who suffered cardiac related deaths has increased the pool of potential liver donors. However, donation after cardiac death (DCD) livers increases the risk of primary graft dysfunction.

Methods

In the current study, we conducted transcriptome sequencing using livers from a DCD rat to assess the short-term feasibility and functional efficacy of DCD livers

SUBMITTER: Chen X 

PROVIDER: S-EPMC6241343 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature