Klinefelter syndrome in males with germ cell tumors: A report from the Children's Oncology Group.

ABSTRACT:

Background

Males with Klinefelter syndrome (KS) (47,XXY) may be more likely to develop germ cell tumors (GCTs), particularly mediastinal GCTs. To date, there are no reports characterizing the prevalence of KS among male GCT cases.

Methods

The authors used array genotyping data from a Children's Oncology Group epidemiology study to estimate the prevalence of KS in males with GCTs (433 males aged birth-19 years). Using Fisher's exact tests, the authors examined differences in age at diagnosis, race/ethnicity, tumor location and histology, and several birth characteristics between cases of KS-GCT and GCT cases without chromosomal abnormalities. Using publicly available data, the authors estimated the 1-year risk, risk ratio, and corresponding 95% confidence interval of GCTs amo

SUBMITTER: Williams LA 

PROVIDER: S-EPMC6241518 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature