Identification of tumor-educated platelet biomarkers of non-small-cell lung cancer.

ABSTRACT:

Background

Lung cancer is a severe cancer with a high death rate. The 5-year survival rate for stage III lung cancer is much lower than stage I. Early detection and intervention of lung cancer patients can significantly increase their survival time. However, conventional lung cancer-screening methods, such as chest X-rays, sputum cytology, positron-emission tomography (PET), low-dose computed tomography (CT), magnetic resonance imaging, and gene-mutation, -methylation, and -expression biomarkers of lung tissue, are invasive, radiational, or expensive. Liquid biopsy is non-invasive and does little harm to the body. It can reflect early-stage dysfunctions of tumorigenesis and enable early detection and intervention.

Methods

In this study, we analyzed RNA-sequencing data of tum

SUBMITTER: Sheng M 

PROVIDER: S-EPMC6241732 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature