Myeloid-derived suppressor cells control B cell accumulation in the central nervous system during autoimmunity.

ABSTRACT: Polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) have been characterized in the context of malignancies. Here we show that PMN-MDSCs can restrain B cell accumulation during central nervous system (CNS) autoimmunity. Ly6G⁺ cells were recruited to the CNS during experimental autoimmune encephalomyelitis (EAE), interacted with B cells that produced the cytokines GM-CSF and interleukin-6 (IL-6), and acquired properties of PMN-MDSCs in the CNS in a manner dependent on the signal transducer STAT3. Depletion of Ly6G⁺ cells or dysfunction of Ly6G⁺ cells through conditional ablation of STAT3 led to the selective accumulation of GM-CSF-producing B cells in the CNS compartment, which in turn promoted an activated microglial phenotype and lack of recovery

SUBMITTER: Knier B 

PROVIDER: S-EPMC6241855 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature