ASSOCIATION OF THE PROTECTIVE FOXO3 LONGEVITY VARIANT WITH TELOMERE DYNAMICS DURING AGING

ABSTRACT: Abstract Telomere attrition in proliferative tissues is a hallmark feature of human aging. To date, identification of genetic influence on the rate of telomere attrition is poorly understood. The two genes with the most robust effect on human longevity are FOXO3 and APOE. Notably, we discovered a genetic variant of the FOXO3 gene that is strongly associated with human longevity. This observation has now been reproduced in independent studies of over a dozen different populations around the world. In the present study, we sought to assess the effect of the longevity associated variant of FOXO3 (rs2802292 - G allele) as well as variants of APOE on telomerase activity and the rate of telomere attrition during aging. The preliminary results from a cohort of Okinawan Japanese (N=120) ranging in

SUBMITTER: Davy P 

PROVIDER: S-EPMC6242152 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature