Probabilistic reinforcement learning abnormalities and their correlates in adolescent bipolar disorders.

ABSTRACT: Theoretical models of bipolar disorders (BD) posit core deficits in reward system function. However, specifying which among the multiple reward system's neurobehavioral processes are abnormal in BD is necessary to develop appropriately targeted interventions. Research on probabilistic-reinforcement learning deficits in BD is limited, particularly during adolescence, a period of significant neurodevelopmental changes in the reward system. The present study investigated probabilistic-reinforcement learning, using a probabilistic selection task (PST), and its correlates, using self-reported reward/threat sensitivities and cognitive tasks, in 104 adolescents with and without BD. Compared with healthy peers, adolescents with BD were less likely to persist with their choices based on prior posit

SUBMITTER: Urosevic S 

PROVIDER: S-EPMC6242350 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature