Metal-free Chlorothiolation of Alkenes using HCl and Sulfoxides.

ABSTRACT: We report a novel method for the chlorothiolation of alkenes using HCl and sulfoxides to achieve the 1,2-difunctionalization of unactivated alkenes. The combination of our new HCl reagent (HCl/DMPU) with sulfoxides forms a unique chlorothiolation system. Both terminal and internal alkenes are suitable substrates. This method works at gram scale and is applicable in further synthetic elaborations.

SUBMITTER: Ebule R 

PROVIDER: S-EPMC6242710 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature