Clinical correlates and heritability of cardiac mechanics: The HyperGEN study.

ABSTRACT:

Background

Indices of cardiac mechanics are sensitive markers of subclinical myocardial dysfunction. Improved understanding of the clinical correlates and heritability of cardiac mechanics could result in novel insight into the acquired and genetic risk factors for myocardial dysfunction. Therefore, we sought to determine the clinical correlates and heritability of indices of cardiac mechanics in whites and African Americans (AAs).

Methods

We examined 2058 participants stratified by race (1104 whites, 954 AA) in the Hypertension Genetic Epidemiology Network (HyperGEN), a population- and family-based study, and performed digitization of analog echocardiograms with subsequent speckle-tracking analysis. We used linear mixed effects models to determine the clinical correlates of

SUBMITTER: Khan SS 

PROVIDER: S-EPMC6242726 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature