A comparison of rodent models of vertical sleeve gastrectomy.

ABSTRACT:

Background

Although vertical sleeve gastrectomy (VSG) is fashioned in humans by applying multiple staple loads, rodent VSG is generally created through a single-staple load application.

Objectives

To investigate the impact of a 2-staple load VSG rat model more closely resembling the multistaple load operation done in humans on weight, metabolic outcomes, and the microbiome and how these compare with those obtained with the standard one-staple load model.

Setting

University research facility, United States.

Methods

High-fat diet-induced obese male rats were randomized to single-staple load VSG (VSG1), 2-staple load VSG (VSG2), or sham operation (Sham). Outcomes included weight and composition, food intake, glucose metabolism, lipids, bile acids, and intestinal m

SUBMITTER: Alvarez R 

PROVIDER: S-EPMC6242744 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature