An anti-clogging method for improving the performance and lifespan of blood plasma separation devices in real-time and continuous microfluidic systems.

ABSTRACT: On-chip blood plasma separators using microfluidic channels are typically developed as disposable devices for short-term use only because blood cells tend to clog the microchannels, limiting their application in real-time and continuous systems. In this study, we propose an anti-clogging method. We applied dielectrophoresis to prevent microchannel clogging in a plasma separator that can be used over long periods for real-time and continuous monitoring. Prior to applying the anti-clogging method, the blood plasma separator stopped working after 4 h. In contrast, by manipulating the separator with the new anti-clogging method at a voltage of 20 V, it continued working in a long-term experiment for 12 h without performance deterioration or an increase in cell loss. Two critical performance pa

SUBMITTER: Kang DH 

PROVIDER: S-EPMC6242854 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature