Properties of cell signaling pathways and gene expression systems operating far from steady-state.

ABSTRACT: Ligand-receptor systems, covalent modification cycles, and transcriptional networks are basic units of signaling systems and their steady-state properties are well understood. However, the behavior of such systems before steady-state is poorly characterized. Here, we analyzed the properties of input-output curves for each of these systems as they approach steady-state. In ligand-receptor systems, the EC₅₀ (concentration of the ligand that occupies 50% of the receptors) is higher before the system reaches steady-state. Based on this behavior, we have previously defined PRESS (for pre-equilibrium sensing and signaling), a general "systems level" mechanism cells may use to overcome input saturation. Originally, we showed that, given a step stimulation, PRESS operates when the kinet

SUBMITTER: Di-Bella JP 

PROVIDER: S-EPMC6242903 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature