Obesity shows preserved plasma proteome in large independent clinical cohorts.

ABSTRACT: Holistic human proteome maps are expected to complement comprehensive profile assessment of health and disease phenotypes. However, methodologies to analyze proteomes in human tissue or body fluid samples at relevant scale and performance are still limited in clinical research. Their deployment and demonstration in large enough human populations are even sparser. In the present study, we have characterized and compared the plasma proteomes of two large independent cohorts of obese and overweight individuals using shotgun mass spectrometry (MS)-based proteomics. Herein, we showed, in both populations from different continents of about 500 individuals each, the concordance of plasma protein MS measurements in terms of variability, gender-specificity, and age-relationship. Additionally, we re

SUBMITTER: Cominetti O 

PROVIDER: S-EPMC6242904 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature