Systematic Analysis of SIN3 Histone Modifying Complex Components During Development.

ABSTRACT: Establishment and maintenance of histone acetylation levels are critical for metazoan development and viability. Disruption of the balance between acetylation and deacetylation by treatment with chemical histone deacetylase (HDAC) inhibitors results in loss of cell proliferation, differentiation and/or apoptosis. Histone deacetylation by the SIN3 complex is essential in Drosophila and mice, as loss of the scaffolding factor SIN3 or the associated HDAC results in lethality. The objective of this study is to elucidate contributions of SIN3 complex components to these essential processes. We used the Drosophila model organism to carry out a systematic functional analysis of the SIN3 complex. We find that SIN3 associated proteins are essential for viability and cell proliferation during develo

SUBMITTER: Barnes VL 

PROVIDER: S-EPMC6242963 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature